Clinical Characterization and Prediction of Clinical Severity of SARS-CoV-2 Infection Among US Adults Using Data From the US National COVID Cohort Collaborative (2021-07-01T00:00:00.000000Z)

TL;DR

It is suggested that machine learning models can be used to predict COVID-19 clinical severity with the use of an available large-scale US CO VID-19 data resource.

Abstract

Key Points Question In a US data resource large enough to adjust for multiple confounders, what risk factors are associated with COVID-19 severity and severity trajectory over time, and can machine learning models predict clinical severity? Findings In this cohort study of 174 568 adults with SARS-CoV-2, 32 472 (18.6%) were hospitalized and 6565 (20.2%) were severely ill, and first-day machine learning models accurately predicted clinical severity. Mortality was 11.6% overall and decreased from 16.4% in March to April 2020 to 8.6% in September to October 2020. Meaning These findings suggest that machine learning models can be used to predict COVID-19 clinical severity with the use of an available large-scale US COVID-19 data resource.

Authors

References35 items

Real-Time Electronic Health Record Mortality Prediction During the COVID-19 Pandemic: A Prospective Cohort Study

Rheumatic disease and COVID-19: epidemiology and outcomes

Association between statin use and outcomes in patients with coronavirus disease 2019 (COVID-19): a nationwide cohort study

The Impact of Dementia on the Clinical Outcome of COVID-19: A Systematic Review and Meta-Analysis

Association Between ABO and Rh Blood Groups and SARS-CoV-2 Infection or Severe COVID-19 Illness

Associations between blood type and COVID-19 infection, intubation, and death

Improving Survival of Critical Care Patients With Coronavirus Disease 2019 in England: A National Cohort Study, March to June 2020*

Obesity as a risk factor for COVID‐19 mortality in women and men in the UK biobank: Comparisons with influenza/pneumonia and coronary heart disease

Patient Trajectories Among Persons Hospitalized for COVID-19

Effect of Hydrocortisone on Mortality and Organ Support in Patients With Severe COVID-19: The REMAP-CAP COVID-19 Corticosteroid Domain Randomized Clinical Trial.

The National COVID Cohort Collaborative (N3C): Rationale, design, infrastructure, and deployment

Clinical Mortality in a Large COVID-19 Cohort: Observational Study

Obesity and Mortality Among Patients Diagnosed With COVID-19: Results From an Integrated Health Care Organization

Risk factors for developing into critical COVID-19 patients in Wuhan, China: A multicenter, retrospective, cohort study

Dexamethasone in Hospitalized Patients with Covid-19 — Preliminary Report

Factors Associated With Death in Critically Ill Patients With Coronavirus Disease 2019 in the US.

Blood type and outcomes in patients with COVID-19

OpenSAFELY: factors associated with COVID-19 death in 17 million patients

A minimal common outcome measure set for COVID-19 clinical research

Retraction—Hydroxychloroquine or chloroquine with or without a macrolide for treatment of COVID-19: a multinational registry analysis

Hospitalization and Mortality among Black Patients and White Patients with Covid-19

ICU and Ventilator Mortality Among Critically Ill Adults With Coronavirus Disease 2019

Disparities In Outcomes Among COVID-19 Patients In A Large Health Care System In California.

High mortality rates for SARS-CoV-2 infection in patients with pre-existing chronic liver disease and cirrhosis: Preliminary results from an international registry

Cardiovascular Disease, Drug Therapy, and Mortality in Covid-19

COVID-19 and the cardiovascular system: implications for risk assessment, diagnosis, and treatment options

Clinical determinants for fatality of 44,672 patients with COVID-19

Presenting Characteristics, Comorbidities, and Outcomes Among 5700 Patients Hospitalized With COVID-19 in the New York City Area.

International electronic health record-derived COVID-19 clinical course profiles: the 4CE consortium

Clinical Characteristics of Covid-19 in New York City

An interactive web-based dashboard to track COVID-19 in real time

Implementation of a Process for Initiating Naltrexone in Patients Hospitalized for Alcohol Detoxification or Withdrawal

The meaning and use of the area under a receiver operating characteristic (ROC) curve.

Writing Committee for the REMAP-CAP Investigators. Effect of hydrocortisone on mortality and organ support in patients with severe

Institutional Development Award Program Infrastructure for Clinical and Translational Research (IDeA-CTR)